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Hypersensitivity to the active substances, to any of the excipients or to other sulfonamide-derived substances (since hydrochlorothiazide is a sulfonamide-derived medicinal product).
Severe renal impairment (creatinine clearance < 30 mL/min).
Refractory hypokalaemia, hypercalcaemia, hyponatraemia and symptomatic hyperuricaemia.
Severe hepatic impairment, cholestasis and biliary obstructive disorders.
2nd and 3rd trimester of pregnancy.
The concomitant use of Olmesartan and Hydrochlorothiazide combination with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m2).
